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Mixture of testosterone called sustanon 250 or 100 is the trademark Organon brand or as other products using the same name is one of the most popular testosterone ester products. Not like most other steroid injectables, Sustanon comprises a mix of esters. To be precise, each ampule or mL contains testosterone propionate 30 mg, testosterone phenylpropionate 60 mg, testosterone isocaproate 60 mg, and testosterone decanoate 100 mg. This mixture includes short, medium, and long-acting esters.


There are two advantages to combining multiple esters in the same formulation as Sustanon does. Here, using multiple esters allows the fairly high total concentration of 250 mg/mL without requiring a large percentage of solubility enhancers in the vehicle. More generally, solubilities of different esters of a steroid are nearly independent of each other, so for example if a vehicle (oil plus solubility enhancers) could dissolve 100 mg/mL of one steroid ester alone or 100 mg/mL of another, it could probably dissolve 200 mg/mL total as a combination of both. This can add convenience.


A second effect of the blending is that extended duration of action can be achieved from having a long-acting ester included in the mix without having the slow onset of action that such esters have when provided alone. From the medical standpoint, it’s desirable that a patient experience benefit shortly after treatment. Sustanon, since it also contains short-acting esters, can accomplish this while also providing a fairly long duration of action.

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From the bodybuilding perspective, this is helpful where the bodybuilder does not know how to frontload a steroid. But if he does, frontloading will accomplish very nearly the same thing, so a different testosterone ester product such as testosterone enanthate can very readily be used in place of Sustanon.


The multiple esters in Sustanon result in slightly complex pharmacokinetics or change in drug level with time. With a single ester, the half-life behavior of a drug is such that after so many hours or so many days blood level falls to one-half of what it had been; then by double that time that falls in half again resulting in one-quarter of the previous level; then by triple that time the level falls to one-eighth of what it had been, etc.


For Sustanon there is no such fixed time period. Estimated approximate values are that after the last injection levels drop to one-half by the 4 day point; to one-quarter by the 10 day point; to one-eighth by the 16 day point; and to one-sixteenth by the 23 day point. Or if preferring to work with round numbers in terms of percent, as approximate values levels drop to 40% by day 6; to 30% by day 8; to 20% by day 11; and to 10% by day 18.


As to how this information is useful: While there is no exact black-and-white value, a good figure to work with is that when clomiphene or tamoxifen is correctly used, recovery of LH production may reasonably begin when levels from injected androgen have fallen to a level commensurate with ongoing 200 mg/week usage.


So let’s say Sustanon was used at 500 mg/week. In this case the user would need levels to fall by 40% before recovery might plausibly begin. We see above that this would be at approximately 6 days after the last injection.


If we had another who used the rather high, but hardly unknown, dosage of 2000 mg per week, he would need for levels to drop to 10% of what they had been. This would be at about 18 days past the last injection.


So much for the matter of the time required between the last injection and the point where recovery could begin. The remaining question regarding Sustanon’s unusual pharmacokinetics is, How to frontload it?


Ordinarily, determining a frontloading value is simple enough, being calculated from the half-life and the dosing schedule. However, Sustanon does not have any one half-life figure, so there is no mathematically perfect answer.


In practice, the amount used for frontloading — the first day’s injection amount — should be that which will on average be taken in 5 days, plus the usual dosage. This total value may be rounded for convenience as exactness isn’t required.


So for example if taking 750 mg/week as three injections of 250 mg each, the average daily rate is 107 mg/day (750 mg divided by 7 days.) So the average taken in 5 days is 535 mg (107 mg/day times 5 days.) Add what will be the usual injection amount which is 250 mg, and our total is 785 mg, which I’d recommend rounding to 750 mg.


After this, subsequent injections are all 250 mg.


This procedure will give proper blood levels much more rapidly than is the case when failing to frontload.


As to dosage, there are many ways to look at it, but a fairly simple and useful one is to categorize usage at increments of 250 mg/week.


Usage of 250 mg/week usually amounts to nothing other than high-end testosterone replacement therapy. There is no guarantee that this usage will even cause testosterone levels to exceed the normal range. The dosing is high enough to suppress LH production, but in most cases is not high enough for any striking anabolic or fat-loss effects. Depending on individual sensitivity, this amount may be high enough to cause gynecomastia if an aromatase inhibitor is not used, or may be enough to cause oily skin or acne. In a few instances, anabolic or fat loss benefits may be impressive, as there are individuals who are high responders. But this isn’t the usual outcome for this dosage level.


500 mg/week. In my opinion, this is a reasonable minimum for an actual steroid cycle. I see little point in suppressing the HPTA but probably failing to get much gains out of it, as is the usual outcome for any dosage much less than this. Again, because testosterone aromatizes to estradiol, an aromatase inhibitor may be required to avoid estrogen-related problems. No one, I think, will fail to see substantially improved gains at this dosage level compared to natural training, but the rate of improvement may be slow. Eight weeks, however, is sufficient even at this amount for a quite significant improvement, unless of course one has trained for enough time at this usage level to have gotten most of what the individual can obtain from it.


750 mg/week. I would rather see this amount used if choosing to do a cycle. If an aromatase inhibitor is used it is unlikely that increased side effects would be a real reason to prefer 500 mg/weeek over this dosage, and results are very substantially superior.


1000 mg/week. I have no problem with this being the dosage for a first cycle but that is in the context of a serious lifter who understands what he is doing. If the steroid use is in fact cycled — that is to say, there are both on and off periods and the on periods are not overly long, and normalization of function is accomplished in the off periods — this is not an overly aggressive dosage by any means. At this dosage, the superiority over natural training is dramatic.


Lastly, there are of course uses such as 2000 mg/week. I don’t see a reason to go to this until one has achieved such a level of development — relative to the individual — that for example 1000 mg/week has done about all that it can do. In that case, if personal goals call for it, a dose such as this can be completely appropriate.


Regardless of dosing level, frequency of injection should be up to twice a week to ensure maximal success.

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